The evidence behind Flow

See real patient outcomes and clinical effectiveness data.

Clinical

Results & Studies

Flow’s results are backed by extensive clinical research and real-world data from thousands of users. Here’s what our science says about our treatment approach.

Users report significant improvement [1]
77%
Average time to notice changes [2]
3 weeks
Report no side effects [3]
95%

Studies

In October 2024, the largest clinical trial into tDCS in the UK and US was published by the authoritative Nature Medicine.

2024 Multi-Center Trial | October 2024
Double-blind study across 12 centers with 1,200 participants showed significant improvement in depression symptoms compared to control group.

Patients who used Flow for 10-weeks were about twice as likely to see their depression go into remission than those in a control group who performed the same procedure with the current switched off.

The placebo-controlled RCT is considered the gold standard method for evaluating efficacy and was carried out by Kings College London, the University of East London and UTHealth Houston.

Published in Nature
See all studies

Tackle more than just your low mood

66%* feel an improvement with their anxiety

Anxiety and depression can be intertwined. 2/3’s of our users felt an improvement of their anxiety after just 3 weeks of treating their depression with Flow.

Sleep better in less than 1 month

1/2 of users experience sleep improvements in 3 weeks

A retrospective-study with over 6,000 people showed that: 1/3 of users reported they no longer had insomnia after just 1 week and 2/3 reported being insomnia free by 10 weeks.

Reinforcing the importance and link between sleep and depression.

See study

Depression-free by week 10

57% were in remission

In the largest clinical trial into tDCS across the UK and US, people using Flow were about twice as likely to see their depression go into remission than those in a control group who performed the same procedure with the current switched off (using a placebo device). 57% of those using Flow were depression-free after 10 weeks.

Flow clinical trial

Feel better in 3 weeks

77% report improvement

We have over 55,000 people using the Flow headset across Europe.
Most people report positive results after 3 weeks; 77% see their depression score improve by at least 3 points. No one has reported a ‘serious’ side effect. Minor side effects include skin irritation and headaches.

Supported by

leading academics

"This is a potential first line treatment for depression. It can also be used for people whose depression hasn’t improved with antidepressant medication, for people who don’t like antidepressant medication, or who don’t want psychotherapy."

Cynthia Fu
Professor of affective neuroscience and psychotherapy, King’s College London
The technology

Understand how our non-invasive treatment technology works to help alleviate depression symptoms.

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Treatment process

Step-by-step guide to using Flow at home for optimal results.

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Footnote
* based on question 2 on the MADRSs Over 18,800 sample of real-world data
[1] Flow real-world data (n=14,383, Apr 2025)
[2] Flow real-world data (n=14,383, Apr 2025)
[3] Flow safety data (n=40,000+) + RCT AE data