Dive into the foundational research for the Flow treatment. Covering neuromodulation, psychological techniques, Flow in practice and our upcoming clinical trials.


Clinical research on tDCS for depression
The Flow brain stimulation treatment is based on decades of clinical research with the most recent meta-analyses showing that tDCS has similar efficacy to other treatments but with fewer side effects.
Across 20+ randomized controlled trials, tDCS has been shown to be superior to placebo/sham and no serious adverse events have been observed. Hence, tDCS provides an alternative to medication that is effective, safe and accessible

Frengi et al. 2021
Frengi et al.
Jul, 2020

tDCS for depression is definitely effective (level A evidence)

Razza et al. 2020
Razza et al.
Feb, 2020

An analysis of 23 clinical trials with 1092 patients, showing that tDCS is superior to placebo/sham

Bikson et al. 2016
Bikson et al.
Jun, 2016

No serious adverse events were found across 33,200 tDCS sessions with 1000 users

Psychological Techniques

Clinical research on behaviour therapy and lifestyle factors depression
The Flow therapy app is based on a hundred years of psychological research, showing that exercise, sleep, diet and meditation all have an impact on reducing depressive symptoms when incorporated into a regular routine.

Murri et al 2019
Murri et al
Aug, 2019

Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes

Hallgren et al.2020
Hallgren et al.
Oct, 2020

Associations of exercise frequency and cardiorespiratory fitness with symptoms of depression and anxiety – a cross-sectional study of 36,595 adults

Lederman et al. 2019
Lederman et al.
Feb, 2019

Does exercise improve sleep quality in individuals with mental illness? A systematic review and meta-analysis

Flow treatment for depression

The Flow treatment has proven effective, both by research trials conducted by third parties and by internal analysis conducted by Flow Neuroscience.
The Flow treatment has been shown in multiple clinical trials to have a positive impact on depression and to reduce depressive symptoms within 3 weeks.
Internal analysis shows 81% of Flow users experiencing an increase in focus, mood and optimism with 30% overcoming depression completely

Borrione 2021
Borrione et al.
Apr, 2021

Open label study showed substantial improvements in 80% of participants

Flow headset expert review
Borrione et al.
Sep, 2020

Computational modeling of the Flow headset stimulation parameters and montage

Rimmer 2022
Rimmer et al.
May, 2022

Participants in open-label trial “would very strongly recommend” Flow

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Would you like to participate in a clinical trial using Flow?

If you are based in England, Wales or Texas and have moderate to severe depression you might be eligible to join a clinical trial using the Flow tDCS headset and contribute to improving the future of depression treatment.