Delve into our extensive evidence base
Flow uses a technology called tDCS (or transcranial Direct Current Stimulation) which has been researched for the past 25 years.
There are now over 20 large, high quality Randomised Controlled Clinical Trials (RCTs) in the literature. Several meta-analyses of these trials have concluded that there is class A evidence (meaning definite effect) for the ability of tDCS to improve depression.
Flow has made tDCS accessible
So why haven’t you heard about tDCS before? Despite the significant amount of research supporting tDCS as a safe and effective depression treatment, historically it has been hard to access. tDCS devices were mainly designed for research, were difficult to use, lacked regulatory approval or were very expensive.
Flow has changed that by designing the first tDCS device which is easy to use, affordable and has regulatory approval to treat depression.
Clinical trial results
In 2023 leading researchers from University of East London and Kings College ran an RCT which compared Flow to a placebo. Participants underwent 10 weeks of tDCS depression treatment using the Flow headset. Results showed that 57% went into remission1 (not clinically depressed) within 10 weeks, and there were no serious side effects2 connected to the use of the device.
57%
Not clinically depressed at 10 weeks
0
Serious side effects
NICE reviews the clinical trial
NICE provides evidence-based guidelines to ensure clinicians deliver the most effective, safe, and cost-efficient care to patients.
In November 2023 they reviewed Flow’s evidence and concluded that "There is high-quality, comparative evidence from the UK that Flow can improve symptoms of depression and lead to remission".
Our work with the NHS
Flow’s tDCS device is now being used in the NHS across primary care, community mental health and perinatal mental health services. Northamptonshire Health Foundations Trust has published two papers endorsing the use of Flow in the NHS.
Primary Care
The 2023 paper concludes “The results...provide support for offering Flow as a primary care-delivered treatment option for people with symptoms of depression. Access to Flow should not be restricted by being able to afford to buy it.”
Community Mental Health
The 2024 paper concludes “These findings provide support for the approach of offering tDCS and at the same time wellbeing behaviour therapy training for CMHT patients experiencing depression. Some people do not wish to try or do not respond to antidepressants or psychotherapy, so it is vital to offer an additional choice of an effective evidence-backed depression treatment that could work for them.”
Real world data from Flow users
The Flow app asks users to fill in a short medical questionnaire3 once per week so that they can track how their symptoms are changing over time. Analysis of aggregated questionnaire data from 4,000 users shows that 46% go into remission or response by week 10.
46%
In remission or response by week 10
Remission is no longer clinically depressed. Response is at least a 50% reduction in depression score.
Leading Doctors and Academics support Flow
Flow’s exciting and encouraging data raise the prospect of a real advance in the treatment of depression…a helpful intervention for many people suffering from major depression.
Allan Young
Chair of Mood Disorders, King’s College London
Flow’s results show a clear separation of active and sham treatment in a large, multisite randomised controlled trial… a very promising development in mental health treatment.
Corey Keller
Assistant Professor of Psychiatry and Behavioural Sciences, Stanford University
Flow has gained popularity among our patients. This positive reception speaks volumes about the effectiveness and patient satisfaction associated with Flow.
Azhar Zafar
GPA Director of Research, NHS GP
With Flow’s brain stimulation headset our highly respected experts now have a new tool to treat depression.
Elena Touroni, PhD
Clinical Director, Chelsea Psychology Clinic
Home-based treatment that is safe and evidence-based. A major step forward for patients with depression.
Sophia Frangou, MD PhD
Professor of Psychiatry, Mount Sinai & Editor-in-Chief of European Psychiatry
By combining tDCS with behavioral therapy, the Flow team has created a powerful treatment solution.
Andre Brunoni, MD PhD
Assoc. Professor of Psychiatry, University Hospital of Sao Paulo
FAQs
Yes. The Flow device was designed by experts and is based on tDCS techniques that have been used in clinics for over a decade to treat depression. The Flow device has undergone research that confirms it is a safe and effective treatment for depression. tDCS is also listed as a treatment for depression on the NHS website.
Read more about Safety and Precautions here.
If the Flow treatment is helpful for the first 10 weeks of your treatment, we recommend you to continue for at least another 6 to 12 months, even if you have become symptom-free.
Our team of clinicians have developed detailed guidance on how to use Flow which you can read here.
Using the headset feels different for everyone. A number of factors will affect how you experience Flow, for example, sleep quality and skin sensitivity and therefore sensations may vary among sessions. It usually feels a little more intense during the first 3 minutes of a stimulation session.
Some people have reported not feeling anything while others have reported feeling an itchy, slightly tingling sensation; like a stinging or a mild burning sensation on the forehead.
A stimulation session takes 30 minutes and can be done whenever works best for you. Whether that be while you eat breakfast to start your day, while replying to emails at work, or even reading while winding down for bed. Flow is a wireless headset that can go wherever you go. Just remember to charge it before use.
Some users have reported feeling energized after stimulation and for those, it would be recommended to use Flow earlier in the day. Some users have reported feeling sleepy after stimulation and for those, it would be ideal to use Flow before going to bed.
Most users do not feel sleepy or energized after a stimulation so it does not matter when the stimulation takes place during the day.
We recommend following the behavioural therapy courses in the app to further support the creation and maintenance of healthy habits that have been proven to help reduce depression.
If you don't want to do that, you don't have to. You can listen to music, watch TV, some of users do puzzles or sudoku whilst stimulating.
It is important to note that the Flow headset should not be used while operating heavy machinery, near water, or while performing intense exercise.
The headset also requires continuous contact to the forehead.
Our real-world data shows that 77% of Flow users experience improvement after just 3 weeks of use. With our 30-day money-back guarantee, you can try Flow and if you find that it doesn’t provide you with the expected results, you can submit a refund request within 30 days of receiving it and receive a full refund.
Please visit our Help Centre to find answers to other commonly asked questions.
References
1As measured by the MADRS-s questionnaire, a widely used depression assessment tool which was administered by a qualified clinician.
2Serious side-effects follow the definition of serious adverse events found in MDR Article 2(58).
3This data is measured using the MADRS-s. The MADRS-s gives an indication of symptom change over time and should not be used for diagnosis.